{"id":5889,"date":"2021-11-11T10:27:38","date_gmt":"2021-11-11T09:27:38","guid":{"rendered":"https:\/\/services.cbmed.at\/html\/old\/?p=5889"},"modified":"2022-03-23T10:32:32","modified_gmt":"2022-03-23T09:32:32","slug":"probiotic-dietary-intervention-in-polycystic-ovary-syndrome-a-randomised-controlled-trial","status":"publish","type":"post","link":"https:\/\/services.cbmed.at\/html\/old\/?p=5889","title":{"rendered":"Probiotic dietary Intervention in Polycystic Ovary Syndrome \u2013 A Randomised Controlled Trial"},"content":{"rendered":"<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h2>Probiotic dietary Intervention in Polycystic Ovary Syndrome \u2013 A Randomised Controlled Trial<\/h2>\n<\/div><\/section>\n<div  class='avia-image-container  av-styling-    avia-builder-el-1  el_after_av_textblock  el_before_av_hr  avia-align-center '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='avia_image' src='https:\/\/services.cbmed.at\/html\/old\/wp-content\/uploads\/2021\/11\/DruckFlyer_ProPCO-RCT_V1.1_16.04.2021.pdf-813x1030.png' alt='Polycystic ovary syndrome (PCOS)' title='Polycystic ovary syndrome (PCOS)' height=\"1030\" width=\"813\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div>\n<div   class='hr hr-default   avia-builder-el-2  el_after_av_image  el_before_av_one_full '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div class=\"flex_column av_one_full  flex_column_div av-zero-column-padding first  avia-builder-el-3  el_after_av_hr  el_before_av_hr  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p><span data-contrast=\"auto\">Polycystic Ovary Syndrome (PCOS) is a hormonal and metabolic disorder caused by elevated androgen levels in women. A variety of symptoms are common, including irregular\/missing menstrual cycles, increased body hair growth or parietal hair loss, unfulfilled child wish, weight gain\/obesity and dysfunctional glucose metabolism, predisposing to type 2 diabetes mellitus.<\/span><span data-ccp-props=\"{\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">These symptoms are most commonly treated either by contraceptive pills or the insulin sensitizer metformin with the potential of severe side effects. Therefore, we aim for new, non-hormonal therapeutic options.<\/span><span data-ccp-props=\"{\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">We recently documented altered gut bacteria composition and reduced gut microbiome diversity in PCOS women (Lindheim et al. 2017, Haudum et al. 2020). Some of these bacteria have a significant impact on hormonal and metabolic regulation making probiotics a potential treatment option for women with PCOS.<\/span><span data-ccp-props=\"{\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The PRO-PCO RCT (randomized controlled trial) is a clinical intervention<\/span><span data-contrast=\"auto\"> in cooperation with Institute Allergosan<\/span><span data-contrast=\"auto\">, including 180 women with PCOS either treated with probiotic, placebo (to test the effectiveness of the probiotics) or metformin (to compare the probiotics to a standard therapy) for six months.<\/span><span data-ccp-props=\"{\">\u00a0<\/span><\/p>\n<\/div><\/section><\/div>\n<div   class='hr hr-default   avia-builder-el-5  el_after_av_one_full  el_before_av_one_full '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div class=\"flex_column av_one_full  flex_column_div av-zero-column-padding first  avia-builder-el-6  el_after_av_hr  el_before_av_hr  \" style='border-radius:0px; '><div  class='avia-image-container  av-styling-    avia-builder-el-7  avia-builder-el-no-sibling  avia-align-center '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='avia_image' src='https:\/\/services.cbmed.at\/html\/old\/wp-content\/uploads\/2021\/11\/1-4-Wochen-1030x496.png' alt='PCOS timeline' title='PCOS timeline' height=\"496\" width=\"1030\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><\/div>\n<div   class='hr hr-default   avia-builder-el-8  el_after_av_one_full  el_before_av_textblock '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p><span data-contrast=\"auto\">Participants attend three visits at our endocrine outpatients\u2019 department at the University Hospital of Graz. Detailed hormonal and metabolic blood analyses including an oral glucose tolerance test, questionnaires and microbiome sampling are assessed. Stool and urine samples are collected at home for microbiome and gut permeability tests. Study medication (probiotics\/placebo\/metformin) is then taken for six months, before returning for the final visit, where the assessments are repeated and further treatment is advised.<\/span><span data-ccp-props=\"{\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The aim of this study is a comprehensive validation of viable alternatives to already existing treatment options for PCOS women, supporting their individual health and quality of life.<\/span><span data-ccp-props=\"{\">\u00a0<\/span><\/p>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":12,"featured_media":5890,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[],"class_list":["post-5889","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cbmed-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.13 - 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