{"id":5622,"date":"2021-06-22T20:09:09","date_gmt":"2021-06-22T18:09:09","guid":{"rendered":"https:\/\/services.cbmed.at\/html\/old\/?p=5622"},"modified":"2021-06-22T20:11:46","modified_gmt":"2021-06-22T18:11:46","slug":"agra","status":"publish","type":"post","link":"https:\/\/services.cbmed.at\/html\/old\/?p=5622","title":{"rendered":"AGRA &#8211; \u201cAcellular Growth Retardation Assay\u201d"},"content":{"rendered":"<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><div id=\"lipsum\">\n<h2>AGRA &#8211; \u201cAcellular Growth Retardation Assay\u201d<\/h2>\n<h3>With AGRA, we invented a reliable, easy to assess, functional biomarker with the possibility for fully automated handling that identifies patients at risk of infection. It is a method to determine the state of the humoral immune system in a patient with liver disease.<\/h3>\n<\/div>\n<p>AGRA is short for \u201cAcellular Growth Retardation Assay\u201d and it is a tool to predict the risk of a patient with liver disease to develop a severe infection. Bacterial infections in patients with cirrhosis are a frequent and life threatening complication. Infections are not only in themselves dangerous, but are a common cause for the deterioration of liver function or the onset of complications with frequently fatal outcome. Up to this point, there was no biomarker which could tell who is at risk to develop infections. This is critical since bacterial infections are often complicated by sepsis, acute renal failure or acute-on-chronic liver failure, prolonging hospital stays and increasing mortality in patients with liver cirrhosis. Therefore, tools to predict severe infections are an urgent clinical need and will help to reach the goal of precision medicine.<\/p>\n<\/div><\/section>\n<div  style='height:50px' class='hr hr-invisible   avia-builder-el-1  el_after_av_textblock  el_before_av_video '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div  class='avia-video avia-video-16-9   av-lazyload-immediate  av-lazyload-video-embed  '   itemprop=\"video\" itemtype=\"https:\/\/schema.org\/VideoObject\"  data-original_url='https:\/\/www.youtube.com\/watch?v=XfFVLupa4go' ><script type='text\/html' class='av-video-tmpl'><div class='avia-iframe-wrap'><iframe loading=\"lazy\" title=\"AGRA - Acellular Growth Retardation Assay\" width=\"1500\" height=\"844\" src=\"https:\/\/www.youtube.com\/embed\/XfFVLupa4go?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/div><\/script><div class='av-click-to-play-overlay'><div class=\"avia_playpause_icon\"><\/div><\/div><\/div>\n<div   class='hr hr-default   avia-builder-el-3  el_after_av_video  el_before_av_textblock '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h5>AGRA: reliable and easy to assess<\/h5>\n<p>With AGRA, <a href=\"https:\/\/services.cbmed.at\/html\/old\/\">CBmed<\/a> has developed a solution: a reliable, easy to assess, functional biomarker with the possibility for fully automated handling that identifies patients at risk of infection. This biomarker is based on the cell free (humoral) immune response of the body that is capable of detecting and killing pathogens. It utilizes the growth tendencies of a specific strain of bacteria in human serum to predict the outcome of a patient. Simply put, the method uses a small amount of serum &#8211; the cell-free component of the blood &#8211; to check if it can kill a specific bacterium. This gives valuable information if a patient to whom the serum belongs will be able to fend off bacteria. Patients with high AGRA have a significantly higher risk to develop severe infections compared to patients with lower AGRA. In patients with chronic hepatitis C infection, AGRA can also be used to track the infection risk during antiviral therapy.<\/p>\n<p>AGRA was developed together by CBmed and the Medical University of Graz. Once more, this proved to be a fruitful collaboration because the <a href=\"https:\/\/www.medunigraz.at\/\">Medical University of Graz<\/a> &#8211; which is also attached to the University Hospital Graz &#8211; has the possibility to define relevant clinical questions and also has access to samples to assess these research questions. At the moment, AGRA is being tested in a clinical study to predict if a patient wo receives a liver transplantation will suffer from a severe infection after transplantation. AGRA will give an outlook into the future of a newly transplanted liver and its recipient and see if this patient will be at risk of developing infections. Ideally, it will be possible to find a way of fine-tuning the immunosuppression that the patients need after trasplantation.<\/p>\n<\/div><\/section>\n<div  style='height:50px' class='hr hr-invisible   avia-builder-el-5  el_after_av_textblock  el_before_av_image '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div  class='avia-image-container  av-styling-    avia-builder-el-6  el_after_av_hr  el_before_av_textblock  avia-align-center '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='avia_image' src='https:\/\/services.cbmed.at\/html\/old\/wp-content\/uploads\/2021\/06\/agra_cbmed_1-1030x687.jpg' alt='' title='agra_cbmed_1' height=\"687\" width=\"1030\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h6 style=\"text-align: center;\">Infection risk of patients with cirrhosis (n=88) according to low or high AGRA. Severe infections required antibiosis and hospitalization.<\/h6>\n<\/div><\/section>\n<div   class='hr hr-default   avia-builder-el-8  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h5>Benefits of the test<\/h5>\n<p>This method can be interesting for different industry-partners. First of all, it is a laboratory test that is using serum, so companies that develop an automatized laboratory test can be interested because they can then develop this method for their platforms and it can be used in routine laboratories. On the other hand, also companies that produce drugs therapeutic agents should be interested in this test, which can be easily done before and during a treatment. All in all, AGRA has great potential. The most promising effects and benefits are:<\/p>\n<p>) predicting the occurrence of severe infections in patients with liver cirrhosis<br \/>\n) accurately identifying patients at risk of infections<br \/>\n) tracking treatment success<br \/>\n) creating personalized risk assessment and treatment of patients with liver cirrhosis.<\/p>\n<p>The patent for this assay has been granted.<\/p>\n<\/div><\/section>\n<div   class='hr hr-default   avia-builder-el-10  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h5 style=\"text-align: center;\">The Authors<\/h5>\n<\/div><\/section>\n<div class=\"flex_column av_one_fourth  flex_column_div av-zero-column-padding first  avia-builder-el-12  el_after_av_textblock  el_before_av_one_fourth  column-top-margin\" style='border-radius:0px; '><div  class='avia-image-container  av-styling-    avia-builder-el-13  avia-builder-el-no-sibling  avia-align-center '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='avia_image' src='https:\/\/services.cbmed.at\/html\/old\/wp-content\/uploads\/2020\/08\/horvath_web-300x300.jpg' alt='' title='horvath_web' height=\"300\" width=\"300\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><\/div>\n<div class=\"flex_column av_one_fourth  flex_column_div av-zero-column-padding   avia-builder-el-14  el_after_av_one_fourth  el_before_av_one_fourth  column-top-margin\" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"text-align: center;\">Angela Horvath, Mag.rer.nat. PhD.<\/p>\n<\/div><\/section><\/div>\n<div class=\"flex_column av_one_fourth  flex_column_div av-zero-column-padding   avia-builder-el-16  el_after_av_one_fourth  el_before_av_one_fourth  column-top-margin\" style='border-radius:0px; '><div  class='avia-image-container  av-styling-    avia-builder-el-17  avia-builder-el-no-sibling  avia-align-center '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='avia_image' src='https:\/\/services.cbmed.at\/html\/old\/wp-content\/uploads\/2020\/08\/stadlbauer_web-300x300.jpg' alt='Vanessa Stadlbauer-K\u00f6llner' title='stadlbauer_web' height=\"300\" width=\"300\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><\/div>\n<div class=\"flex_column av_one_fourth  flex_column_div av-zero-column-padding   avia-builder-el-18  el_after_av_one_fourth  avia-builder-el-last  column-top-margin\" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"text-align: center;\">Assoz. Prof.in Priv.-Doz.in Dr.in med.univ. Vanessa Stadlbauer-K\u00f6llner<\/p>\n<\/div><\/section><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":12,"featured_media":5619,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[],"class_list":["post-5622","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cbmed-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.13 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>AGRA - \u201cAcellular Growth Retardation Assay\u201d | CBmed GmbH Center for Biomarker Research in Medicine<\/title>\n<meta name=\"description\" content=\"AGRA is a method developed by CBmed to determine the state of the humoral immune system in a patient with liver disease, predicting bacterial infections.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AGRA - \u201cAcellular Growth Retardation Assay\u201d | CBmed GmbH Center for Biomarker Research in Medicine\" \/>\n<meta property=\"og:description\" content=\"AGRA is a method developed by CBmed to determine the state of the humoral immune system in a patient with liver disease, predicting bacterial infections.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/services.cbmed.at\/html\/old\/?p=5622\" \/>\n<meta property=\"og:site_name\" content=\"CBmed GmbH Center for Biomarker Research in Medicine\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-22T18:09:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-06-22T18:11:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/services.cbmed.at\/html\/old\/wp-content\/uploads\/2021\/06\/agra_blog_cbmed.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sindhushri Rao\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sindhushri Rao\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/services.cbmed.at\/html\/old\/?p=5622#article\",\"isPartOf\":{\"@id\":\"https:\/\/services.cbmed.at\/html\/old\/?p=5622\"},\"author\":{\"name\":\"Sindhushri Rao\",\"@id\":\"https:\/\/services.cbmed.at\/html\/old\/#\/schema\/person\/33ba32447f623be7f9d38b5016156694\"},\"headline\":\"AGRA &#8211; 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